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| Registros recuperados: 10 | |
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| TIETBOHL,LUIS A.C.; OLIVEIRA,ADRIANA P.; ESTEVES,RICARDO S.; ALBUQUERQUE,RICARDO D.D.G.; FOLLY,DIOGO; MACHADO,FRANCISCO P.; CORRÊA,ARTHUR L.; SANTOS,MARCELO G.; RUIZ,ANA L.G.; ROCHA,LEANDRO. |
| ABSTRACT Myrciaria floribunda (H. West ex Willd.) O. Berg, Myrtaceae, is a native plant species of the Atlantic Rain Forest, from north to south of Brazil. The lyophilized ethyl acetate extract from the leaves of M. floribunda was investigated for its antiproliferative activity in tumor cell lines, antioxidant capacity and its total phenolic, flavonoid and tannin contents. Antiproliferative activity was tested in vitro against seven human cancer cells and against immortalized human skin keratinocytes line (HaCat, no cancer cell). Antioxidant activity was determined using 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and oxygen radical absorbing capacity (ORAC) assays and total phenolic, flavonoid and tannin contents were determined by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiproliferative; Flavonoids; Myrciaria floribunda; Phenols. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301111 |
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| OLIVEIRA,SIMONE Q.; KRATZ,JADEL M.; CHAVES,VITOR C.; GUIMARÃES,TATIANA R.; COSTA,DANIELLE T.M.; DIMITRAKOUDI,SAPFO; VONTZALIDOU,ARGYRO; BORDIGNON,SÉRGIO A.L.; SIMIONATO,CESAR P.; STEINDEL,MÁRIO; REGINATTO,FLÁVIO H.; SIMÕES,CLÁUDIA M.O.; SCHENKEL,ELOIR P.. |
| Abstract: Aristolochia triangularis Cham., is one of the most frequently used medicinal plant in Southern Brazil. Preparations containing the leaves and/or stems are traditionally used as anti-inflammatory, diuretic, as well as antidote against snakebites. This study screened A. triangularis extracts, fractions and isolated compounds for different bioactivities. A weak antiproliferative activity against human lung cancer cell line (A549) was observed only for chloroform fraction obtained from stems (CFstems - CC50: 2.93 µg/mL). Also, a moderate antimicrobial activity against Staphylococcus aureus was detected just for chloroform fraction obtained from leaves (CFleaves -13-16 mm inhibition zone). Additionally, two semi-purified fractions (CFstems-4 and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aristolochia triangularis; Antiproliferative; Antiherpes; Antimicrobial; Antiprotozoal; Aristolochic acids. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500801 |
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| Magalhães,Hemerson I.F.; Ferreira,Paulo M.P.; Moura,Eraldo S.; Torres,Márcia R.; Alves,Ana P.N.N.; Pessoa,Otília D.L.; Costa-Lotufo,Letícia V.; Moraes,Manoel O.; Pessoa,Cláudia. |
| The cytotoxic potential of stem organic extracts from Calotropis procera (Asclepiadaceae) was firstly evaluated against cancer cell lines by MTT assay. Subsequently, samples considered cytotoxic were tested for antimitotic activity on sea urchin egg development and for in vivo antiproliferative activity in mice bearing Sarcoma 180 tumor. Among the five extracts (hexane, dichloromethane, ethyl acetate, acetone and methanol), ethyl acetate and acetone extracts displayed higher cytotoxic potential against tumor cells, with IC50 ranging from 0.8 to 4.4 μg/mL, while methanolic extract was weakly cytotoxic. Cytotoxic extracts also exhibited cell division inhibition capacity by antimitotic assay, revealing IC50 values lower than 5 μg/mL. In the in vivo antitumor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimitotic; Antiproliferative; Calotropis procera; Sarcoma 180 tumor; Stem extracts. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200017 |
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| LAHNECHE,AMINA M.; BOUCHEHAM,RATIBA; OZEN,TEVFIK; ALTUN,MUHAMMED; BOUBEKRI,NASSIMA; DEMIRTAS,IBRAHIM; BICHA,SABRINA; BENTAMENE,ALI; BENAYACHE,FADILA; BENAYACHE,SAMIR; ZAMA,DJAMILA. |
| Abstract: This study aimed to evaluate the in vitro antiproliferative and inhibition of oxidative DNA-damage activities of n-butanol (n-BuOH) extract of Centaurea sphaerocephala. The in vitro antioxidant activity of the ethyl acetate (EtOAc) and the n-BuOH extracts of this plant were also assayed. To investigate the antioxidant potential, extracts were tested for their capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH·) and to inhibit lipid peroxidation using the TBARs method. The contents of total phenolics and flavonoids were measured. Additionally, antiproliferative activity and DNA-damage inhibition of the n-BuOH extract was determined using XCELLigence RTCA instrument and photolyzing 46966 plasmid, respectively. The results exhibited that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Centaurea sphaerocephala; Phenolics; Antioxidant; Lipid peroxidation; Antiproliferative; DNA-damaged inhibition. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500619 |
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| Formagio,A.S.N.; Vieira,M.C.; Volobuff,C.R.F.; Silva,M.S.; Matos,A.I.; Cardoso,C.A.L.; Foglio,M.A.; Carvalho,J.E.. |
| The aim of this research was to investigate the antiproliferative and anticholinesterase activities of 11 extracts from 5 Annonaceae species in vitro. Antiproliferative activity was assessed using 10 human cancer cell lines. Thin-layer chromatography and a microplate assay were used to screen the extracts for acetylcholinesterase (AchE) inhibitors using Ellman's reagent. The chemical compositions of the active extracts were investigated using high performance liquid chromatography. Eleven extracts obtained from five Annonaceae plant species were active and were particularly effective against the UA251, NCI-470 lung, HT-29, NCI/ADR, and K-562 cell lines with growth inhibition (GI50) values of 0.04-0.06, 0.02-0.50, 0.01-0.12, 0.10-0.27, and 0.02-0.04 µg/mL,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Annona; Duguetia; Antiproliferative; Anticholinesterase activity. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400308 |
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| SANTOS,TÁSSIA L.A. DOS; QUEIROZ,RAPHAEL F.; SAWAYA,ALEXANDRA C.H.F.; LOPEZ,BEGOÑA GIMENEZ-CASSINA; SOARES,MILENA B.P.; BEZERRA,DANIEL P.; RODRIGUES,ANA CAROLINA B.C.; PAULA,VANDERLÚCIA F. DE; WALDSCHMIDT,ANA MARIA. |
| ABSTRACT Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of geopropolis, but there have been no previous studies of the geopropolis from Melipona mondury. In this study, we investigated the antioxidant, antibacterial, and antiproliferative activities of M. mondury geopropolis, and determined its chemical profile. The antioxidant activity was determined using in vitro ABTS·+, ·DPPH, and β-carotene/linoleic acid co-oxidation methods. The antibacterial activity was determined using a microdilution method with Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S. aureus. The antiproliferative effect was determined in tumor cell lines using the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antibacterial; Antioxidant; Antiproliferative; Geopropolis; Melipona mondury. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502247 |
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| Kumar,Rakesh; Arora,Rohit; Mahajan,Jyoti; Mahey,Sonia; Arora,Saroj. |
| ABSTRACT Oxidative stress, being the main cause of most of the human diseases, has always been the highlight of research worldwide. This stress can be overcome by administration of natural polyphenols. The Acacia catechu Willd. has many refrences available in Ayurveda as important disease curative plant. Its leaves are investigated for ameliorating oxidative stress in present work. Leaves of A. catechu were extracted with 80% methanol to get methanol extract (AME). It was assessed for antioxidant activity using DPPH, ABTS, CUPRAC, ferric ion reducing, superoxide scavenging and peroxyl radical scavenging assays. DNA protective activity was also investigated using plasmid nicking assay. Further, antiproliferative activity was determined using MTT assay in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acacia catechu; Antioxidant; Antiproliferative; UHPLC; MTT.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100303 |
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| Kumar,Rakesh; Arora,Rohit; Mahajan,Jyoti; Mahey,Sonia; Arora,Saroj. |
| ABSTRACT Oxidative stress, being the main cause of most of the human diseases, has always been the highlight of research worldwide. This stress can be overcome by administration of natural polyphenols. The Acacia catechu Willd. has many refrences available in Ayurveda as important disease curative plant. Its leaves are investigated for ameliorating oxidative stress in present work. Leaves of A. catechu were extracted with 80% methanol to get methanol extract (AME). It was assessed for antioxidant activity using DPPH, ABTS, CUPRAC, ferric ion reducing, superoxide scavenging and peroxyl radical scavenging assays. DNA protective activity was also investigated using plasmid nicking assay. Further, antiproliferative activity was determined using MTT assay in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acacia catechu; Antioxidant; Antiproliferative; UHPLC; MTT. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100316 |
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| Aguiñiga Sánchez, Itzen. |
| El género Sechium (Cucurbitaceae) está formado por 10 especies, entre ellas Sechuim compositum, Sechium chinantlense y Sechium edule (Jacq.) Sw.; solo esta última es fuente medicinal y de alimento, de la cual se ha generado el híbrido H-387-07-GISeM a partir de sus diversas variedades. En este trabajo se analiza el contenido de los principales grupos de metabolitos contenido en extractos de frutos de Sechuim compositum, Sechium chinantlense y H-387-07-GISeM, la actividad antiproliferativa del extracto completo o fraccionado, así como el mecanismo de inhibición de la proliferación tanto en células leucémicas WEHI-3 como en células hematopoyéticas normales. En todas las especies estudiadas, los principales metabolitos detectados fueron terpenos y... |
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Palavras-chave: Cucurbitaceae; Antiproliferativo; Apoptosis; Fitoquímica; Antiproliferative; Phytochemical; Botánica; Maestría. |
| Ano: 2013 |
URL: http://hdl.handle.net/10521/1968 |
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| Registros recuperados: 10 | |
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